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butabarbital will reduce the level or impact of zonisamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Mysterious.butabarbital boosts results of ifosfamide by impacting hepatic enzyme CYP2B6 metabolism. Use Warning/Observe. Coadministration of ifosfamide with CYP2B6 inducers could enhance metabolism of ifosfamide to